SEROTONIN UPTAKE INHIBITORS
\sˌɛɹətˈə͡ʊnɪn ˈʌpte͡ɪk ɪnhˈɪbɪtəz], \sˌɛɹətˈəʊnɪn ˈʌpteɪk ɪnhˈɪbɪtəz], \s_ˌɛ_ɹ_ə_t_ˈəʊ_n_ɪ_n ˈʌ_p_t_eɪ_k ɪ_n_h_ˈɪ_b_ɪ_t_ə_z]\
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Compounds that specifically inhibit the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. These agents have been used in treatment of depression, panic disorder, obsessive-compulsive behavior, and alcoholism, as analgesics, and to treat obesity and bulimia. Many of the ADRENERGIC UPTAKE INHIBITORS also inhibit serotonin uptake; they are not included here.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.