SC9420
\ˌɛssˈiː nˈa͡ɪn θˈa͡ʊzənd fˈɔːhˈʌndɹədən twˈɛnti], \ˌɛssˈiː nˈaɪn θˈaʊzənd fˈɔːhˈʌndɹədən twˈɛnti], \ˌɛ_s_s_ˈiː n_ˈaɪ_n θ_ˈaʊ_z_ə_n_d f_ˈɔː_h_ˈʌ_n_d_ɹ_ə_d_ə_n t_w_ˈɛ_n_t_i]\
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A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.