RO 318959

\ɹˈə͡ʊ θɹˈiːhˈʌndɹədən ˈe͡ɪtiːn θˈa͡ʊzənd nˈa͡ɪnhˈʌndɹədən fˈɪftinˈa͡ɪn], \ɹˈə‍ʊ θɹˈiːhˈʌndɹədən ˈe‍ɪtiːn θˈa‍ʊzənd nˈa‍ɪnhˈʌndɹədən fˈɪftinˈa‍ɪn], \ɹ_ˈəʊ θ_ɹ_ˈiː_h_ˈʌ_n_d_ɹ_ə_d_ə_n ˈeɪ_t_iː_n θ_ˈaʊ_z_ə_n_d_ n_ˈaɪ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n f_ˈɪ_f_t_i_n_ˈaɪ_n]\

Definitions of RO 318959

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Proto Oncogene Proteins c erbB 2

  • cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
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