RADDLED
\ɹˈadə͡ld], \ɹˈadəld], \ɹ_ˈa_d_əl_d]\
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showing the wearing effects of overwork or care or suffering; "looking careworn as she bent over her mending"; "her face was drawn and haggard from sleeplessness"; "that raddled but still noble face"; "shocked to see the worn look of his handsome young face"- Charles Dickens
By Princeton University
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.