PRIONS
\pɹˈa͡ɪɒnz], \pɹˈaɪɒnz], \p_ɹ_ˈaɪ_ɒ_n_z]\
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Small proteinaceous infectious particles which resist inactivation by procedures that modify nucleic acids and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME and GERSTMANN-STRAUSSLER SYNDROME.
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Photofrin II
- purified component HEMATOPORPHYRIN DERIVATIVE, consists a mixture oligomeric porphyrins. used therapy (PHOTORADIATION); treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in use of photodynamic therapy United States.