PRION PROTEINS
\pɹˈa͡ɪɒn pɹˈə͡ʊtiːnz], \pɹˈaɪɒn pɹˈəʊtiːnz], \p_ɹ_ˈaɪ_ɒ_n p_ɹ_ˈəʊ_t_iː_n_z]\
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Small proteinaceous infectious particles which resist inactivation by procedures that modify nucleic acids and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME and GERSTMANN-STRAUSSLER SYNDROME.
By DataStellar Co., Ltd
