PRENYLTRANSFERASE
\pɹˈɛnɪltɹɐnsfˌɜːɹe͡ɪz], \pɹˈɛnɪltɹɐnsfˌɜːɹeɪz], \p_ɹ_ˈɛ_n_ɪ_l_t_ɹ_ɐ_n_s_f_ˌɜː_ɹ_eɪ_z]\
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An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.