PORCINE XENOGRAFT BIOPROSTHESIS
\pˈɔːsiːn zˈɛnəɡɹˌaft bˌa͡ɪə͡ʊpɹˈɒsθəsˌɪs], \pˈɔːsiːn zˈɛnəɡɹˌaft bˌaɪəʊpɹˈɒsθəsˌɪs], \p_ˈɔː_s_iː_n z_ˈɛ_n_ə_ɡ_ɹ_ˌa_f_t b_ˌaɪ_əʊ_p_ɹ_ˈɒ_s_θ_ə_s_ˌɪ_s]\
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Prosthesis, usually heart valve, composed of biological material and whose durability depends upon the stability of the material after pretreatment, rather than regeneration by host cell ingrowth. Durability is achieved 1) mechanically by the interposition of a cloth, usually polytetrafluoroethylene, between the host and the graft, and 2) chemically by stabilization of the tissue by intermolecular linking, usually with glutaraldehyde, after removal of antigenic components, or the use of reconstituted and restructured biopolymers.
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