POISONING, 1 METHYL 4 PHENYL 1,2,3,6 TETRAHYDROPYRIDINE
\pˈɔ͡ɪzənɪŋ], \pˈɔɪzənɪŋ], \p_ˈɔɪ_z_ə_n_ɪ_ŋ]\
Definitions of POISONING, 1 METHYL 4 PHENYL 1,2,3,6 TETRAHYDROPYRIDINE
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A condition caused by the neurotoxin 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. MPTP causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36 (2):250-8)
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- A religious sect among East Indians who believe in transmigration of souls, and consequently abstain from use the flesh animals.