PLURONIC F108
\plʊ͡əɹˈɒnɪk ˈɛf wˈɒnhˈʌndɹədən ˈe͡ɪt], \plʊəɹˈɒnɪk ˈɛf wˈɒnhˈʌndɹədən ˈeɪt], \p_l_ʊə_ɹ_ˈɒ_n_ɪ_k ˈɛ_f w_ˈɒ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n ˈeɪ_t]\
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A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO (C2H4O)a (-C3H6O)b (C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilising agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.