PIGMENTARY PALLIDAL DEGENERATION
\pɪɡmˈɛntəɹi pˈalɪdə͡l dɪd͡ʒˌɛnəɹˈe͡ɪʃən], \pɪɡmˈɛntəɹi pˈalɪdəl dɪdʒˌɛnəɹˈeɪʃən], \p_ɪ_ɡ_m_ˈɛ_n_t_ə_ɹ_i p_ˈa_l_ɪ_d_əl d_ɪ_dʒ_ˌɛ_n_ə_ɹ_ˈeɪ_ʃ_ə_n]\
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A rare autosomal recessive degenerative disorder which usually presents in late childhood or adolescence. Clinical manifestations include progressive MUSCLE SPASTICITY; hyperreflexia; MUSCLE RIGIDITY; DYSTONIA; DYSARTHRIA; and intellectual deterioration which progresses to severe dementia over several years. Pathologic examination reveals neuronal atrophy in the globus pallidus and iron deposition in blood vessels and perivascular spaces. (From Adams et al., Principles of Neurology, 6th ed, p972; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp972-929)
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sir richard blackmore
- An English physician poet; born in Wiltshire about 1650; died 1729. Besides medical works, Scripture paraphrases, satirical verse, he wrote Popian couplets "Prince Arthur, a Heroic Poem"(1695), and voluminous religious epic, "The Creation"(1712), very successful much praised then, but not now read.