PHOSPHOTYROSYL PROTEIN PHOSPHATASE
\fˈɒsfətˌɪɹəsˌɪl pɹˈə͡ʊtiːn fˈɒsfɐtˌe͡ɪs], \fˈɒsfətˌɪɹəsˌɪl pɹˈəʊtiːn fˈɒsfɐtˌeɪs], \f_ˈɒ_s_f_ə_t_ˌɪ_ɹ_ə_s_ˌɪ_l p_ɹ_ˈəʊ_t_iː_n f_ˈɒ_s_f_ɐ_t_ˌeɪ_s]\
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An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. EC 3.1.3.48.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.