PERIVENTRICULAR LEUKOMALACIA
\pˌɛɹɪvɪntɹˈɪkjʊlə lˌuːkəmɐlˈe͡ɪʃə], \pˌɛɹɪvɪntɹˈɪkjʊlə lˌuːkəmɐlˈeɪʃə], \p_ˌɛ_ɹ_ɪ_v_ɪ_n_t_ɹ_ˈɪ_k_j_ʊ_l_ə l_ˌuː_k_ə_m_ɐ_l_ˈeɪ_ʃ_ə]\
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Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and COGNITIVE DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)
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