OPTIC ATROPHY, LEBER, HEREDITARY
\ˈɒptɪk ˈatɹəfi], \ˈɒptɪk ˈatɹəfi], \ˈɒ_p_t_ɪ_k ˈa_t_ɹ_ə_f_i]\
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A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))
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Elizabeth Sara Sheppard
- An English novelist; born at Blackheath, 1830; died Brixton, March 13, 1862. She wrote noted "Charles Auchester"(1853), mystical art novel; "Counterparts, or the Cross of Love"(1854); "My First Season"(1855); "The Double Coronet"(1856); "Rumor", a musical and artistic novel(1858).