OBJECTIVE SIGN
\ɒbd͡ʒˈɛktɪv sˈa͡ɪn], \ɒbdʒˈɛktɪv sˈaɪn], \ɒ_b_dʒ_ˈɛ_k_t_ɪ_v s_ˈaɪ_n]\
Definitions of OBJECTIVE SIGN
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.