\nəɡˈʌt͡ʃɪ tˈɛst], \nəɡˈʌtʃɪ tˈɛst], \n_ə_ɡ_ˈʌ_tʃ_ɪ t_ˈɛ_s_t]\
Definitions of NOGUCHI TEST
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1. A test for tabes or general paralysis, depending upon a specific albumin reaction of the spinal fluid: o. 1 c.c. of the spinal fluid to be tested is placed in a test-tube whose diameter is 1 cm. or less. To this is added 0.5 c.c. of a 10 per cent, solution of butyric acid. The tube is now heated until the fluid is bubbling, and while still hot o. 1 c.c. of a normal (4 per cent.) solution of sodium hydrate is added. In nearly all spinal fluids an opalescence or cloud occurs, but in the spinal fluid of general paralysis the cloud soon separates into a definite flocculence which is characteristic. 2. A test for syphilis, a modification of the Wassermann method: The antigen is a lipoid substance extracted from the liver and heart; human corpuscles instead of sheep's corpuscles are used, and the hemolytic ambocepter is obtained by immunizing rabbits against normal. human erythrocytes. The hemolytic ambocepter and antigen are preserved by soaking filter paper and drying. The antigen filter paper is placed in human serum, guinea-pig's serum is added and both are diluted with isotonic salt solution; after this has stood a definite time at incubator temperature the hemolytic amboceptor paper and a definite quantity of washed normal human erythrocytes are added. 3. Luetin test, cutireaction test; a drop of luetin is injected intracutaneously, and if syphilis is present a large, reddish indurated papule surrounded with a purplish areola appears within 24 to 48 hours.
By Stedman, Thomas Lathrop