NOCTURNAL PAROXYSMAL HEMOGLOBINURIA
\nɒktˈɜːnə͡l pˈaɹəksˌɪsmə͡l hˌiːməɡlˌɒbɪnjˈʊɹi͡ə], \nɒktˈɜːnəl pˈaɹəksˌɪsməl hˌiːməɡlˌɒbɪnjˈʊɹiə], \n_ɒ_k_t_ˈɜː_n_əl p_ˈa_ɹ_ə_k_s_ˌɪ_s_m_əl h_ˌiː_m_ə_ɡ_l_ˌɒ_b_ɪ_n_j_ˈʊ_ɹ_iə]\
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Disorder characterized by intravascular hemolysis and hemoglobinuria. Some cases occur on exposure to cold and are due to the presence of an autohemolysin in the serum. Other cases are more marked during or immediately after sleep and are considered to be due to an acquired intracorpuscular defect.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.