MUROMONAB CD3
\mjˈʊɹəmˌɒnab sˌiːdˈiː θɹˈiː], \mjˈʊɹəmˌɒnab sˌiːdˈiː θɹˈiː], \m_j_ˈʊ_ɹ_ə_m_ˌɒ_n_a_b s_ˌiː_d_ˈiː θ_ɹ_ˈiː]\
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Anti-CD3 monoclonal antibody that exerts immunosuppressive effects by inducing peripheral T-cell depletion and modulation of the T-cell receptor complex (CD3/Ti). This biochemically purified IMMUNOGLOBULIN G is obtained through the fusion of mouse myeloma cells to lymphocytes from immunized animals to produce hybridomas that secrete specific antibodies to the T3 (CD3) antigens of human T-lymphocytes. It is often used as an immunosuppressive agent in transplantation.
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Word of the day
Collagen Induced Arthritis
- ARTHRITIS that is induced in experimental animals. Immunological and infectious agents can be used to develop models. These methods include injections of stimulators the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.