MULTISPECIFIC ORGANIC ANION TRANSPORTER
\mˌʌltɪspəsˈɪfɪk ɔːɡˈanɪk ˈana͡ɪən tɹanspˈɔːtə], \mˌʌltɪspəsˈɪfɪk ɔːɡˈanɪk ˈanaɪən tɹanspˈɔːtə], \m_ˌʌ_l_t_ɪ_s_p_ə_s_ˈɪ_f_ɪ_k ɔː_ɡ_ˈa_n_ɪ_k ˈa_n_aɪ_ə_n t_ɹ_a_n_s_p_ˈɔː_t_ə]\
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A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
By DataStellar Co., Ltd
Word of the day
hydromorphic
- [Greek] Structurally adapted to an aquatic environment, as organs of water plants.
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