MULTIPLE TUMOR SUPPRESSOR 1
\mˈʌltɪpə͡l tjˈuːmə səpɹˈɛsə wˈɒn], \mˈʌltɪpəl tjˈuːmə səpɹˈɛsə wˈɒn], \m_ˈʌ_l_t_ɪ_p_əl t_j_ˈuː_m_ə s_ə_p_ɹ_ˈɛ_s_ə w_ˈɒ_n]\
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A gene product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member the INK4 family - inhibitors of cyclin-dependent kinase CDK4. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is P14ARF PROTEIN. Both p16 gene products have tumor suppressor functions.
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.