MULTINUCLEATED GIANT CELL
\mˌʌltɪnjˈuːklɪˌe͡ɪtɪd d͡ʒˈa͡ɪənt sˈɛl], \mˌʌltɪnjˈuːklɪˌeɪtɪd dʒˈaɪənt sˈɛl], \m_ˌʌ_l_t_ɪ_n_j_ˈuː_k_l_ɪ__ˌeɪ_t_ɪ_d dʒ_ˈaɪ_ə_n_t s_ˈɛ_l]\
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Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
By DataStellar Co., Ltd
Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.