MERKEL CELL CARCINOMA
\mˈɜːkə͡l sˈɛl kˌɑːsɪnˈə͡ʊmə], \mˈɜːkəl sˈɛl kˌɑːsɪnˈəʊmə], \m_ˈɜː_k_əl s_ˈɛ_l k_ˌɑː_s_ɪ_n_ˈəʊ_m_ə]\
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A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.