MASSIVE OSTEOLYSIS
\mˈasɪv ˌɒstɪˈɒləsˌɪs], \mˈasɪv ˌɒstɪˈɒləsˌɪs], \m_ˈa_s_ɪ_v ˌɒ_s_t_ɪ__ˈɒ_l_ə_s_ˌɪ_s]\
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Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (Hajdu-Cheney syndrome, Winchester syndrome), or carpal/tarsal.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.