MANTLE CELL LYMPHOMA
\mˈantə͡l sˈɛl lɪmfˈə͡ʊmə], \mˈantəl sˈɛl lɪmfˈəʊmə], \m_ˈa_n_t_əl s_ˈɛ_l l_ɪ_m_f_ˈəʊ_m_ə]\
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A rare form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t (11;14) translocation resulting in overexpression of the cyclin D1 gene (GENES, BCL-1).
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.