MANTLE ZONE LYMPHOMA
\mˈantə͡l zˈə͡ʊn lɪmfˈə͡ʊmə], \mˈantəl zˈəʊn lɪmfˈəʊmə], \m_ˈa_n_t_əl z_ˈəʊ_n l_ɪ_m_f_ˈəʊ_m_ə]\
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A rare form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t (11;14) translocation resulting in overexpression of the cyclin D1 gene (GENES, BCL-1).
By DataStellar Co., Ltd
