MAMMALIAN ARTIFICIAL CHROMOSOMES
\mamˈe͡ɪli͡ən ˌɑːtɪfˈɪʃə͡l kɹˈə͡ʊməsˌə͡ʊmz], \mamˈeɪliən ˌɑːtɪfˈɪʃəl kɹˈəʊməsˌəʊmz], \m_a_m_ˈeɪ_l_iə_n ˌɑː_t_ɪ_f_ˈɪ_ʃ_əl k_ɹ_ˈəʊ_m_ə_s_ˌəʊ_m_z]\
Definitions of MAMMALIAN ARTIFICIAL CHROMOSOMES
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DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, that are required for successful replication, propagation to and maintainance in progeny mammalian cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.
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- Diminished sensibility.