MALE BREAST NEOPLASMS
\mˈe͡ɪl bɹˈɛst nˈiːə͡ʊplˌazəmz], \mˈeɪl bɹˈɛst nˈiːəʊplˌazəmz], \m_ˈeɪ_l b_ɹ_ˈɛ_s_t n_ˈiː__əʊ_p_l_ˌa_z_ə_m_z]\
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Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females. Two-thirds of patients present with intraductal carcinoma. The average age of onset is 60 years for men. Orchiectomy was the standard treatment but it has been replaced by TAMOXIFEN as the initial therapy since estrogen-receptor-positive tumors are predominant in males. Orchiectomy and mastectomy may be used if initial drug therapy is not successful. The prognosis is worse than that for females. (From Holland, et al., Cancer Medicine, 3d ed, p1751)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.