LUPUS ANTICOAGULANT
\lˈuːpəs ˌantɪkə͡ʊˈaɡjʊlənt], \lˈuːpəs ˌantɪkəʊˈaɡjʊlənt], \l_ˈuː_p_ə_s ˌa_n_t_ɪ_k_əʊ_ˈa_ɡ_j_ʊ_l_ə_n_t]\
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An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC), ANTIPHOSPHOLIPID SYNDROME, and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.