LIPID HYDROPEROXIDE
\lˈɪpɪd hˌa͡ɪdɹə͡ʊpɹˈɒksa͡ɪd], \lˈɪpɪd hˌaɪdɹəʊpɹˈɒksaɪd], \l_ˈɪ_p_ɪ_d h_ˌaɪ_d_ɹ_əʊ_p_ɹ_ˈɒ_k_s_aɪ_d]\
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Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.