L 3,4 DIHYDROXYPHENYLALANINE
\ˈɛl θɹˈiː fˈɔː da͡ɪhˈa͡ɪdɹəksɪfˌiːna͡ɪlˌalɐnˌa͡ɪn], \ˈɛl θɹˈiː fˈɔː daɪhˈaɪdɹəksɪfˌiːnaɪlˌalɐnˌaɪn], \ˈɛ_l θ_ɹ_ˈiː f_ˈɔː d_aɪ_h_ˈaɪ_d_ɹ_ə_k_s_ɪ_f_ˌiː_n_aɪ_l_ˌa_l_ɐ_n_ˌaɪ_n]\
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The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
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