KARYOPHERIN ALPHA
\kˈaɹɪəfəɹˌɪn ˈalfə], \kˈaɹɪəfəɹˌɪn ˈalfə], \k_ˈa_ɹ_ɪ__ə_f_ə_ɹ_ˌɪ_n ˈa_l_f_ə]\
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Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNAL of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUCCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.