KALLMANN SYNDROME
\kˈalman sˈɪndɹə͡ʊm], \kˈalman sˈɪndɹəʊm], \k_ˈa_l_m_a_n s_ˈɪ_n_d_ɹ_əʊ_m]\
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Congenital and familial disorder characterized by hypogonadotropic hypogonadism, eunuchoidal features, and anosmia or hyposmia. It is caused by a defect in the synthesis and/or release of LHRH (luteinizing hormone-releasing hormone; GONADORELIN) from the hypothalamus as a result of faulty embryonic neuronal migration. The gene responsible for this is found in the region Xp22.3 on the short arm of the X chromosome. There is a homolog on the Y chromosome. The syndrome is more prevalent in males by a ratio of three to one.
By DataStellar Co., Ltd
