JOINING REGION
\d͡ʒˈɔ͡ɪnɪŋ ɹˈiːd͡ʒən], \dʒˈɔɪnɪŋ ɹˈiːdʒən], \dʒ_ˈɔɪ_n_ɪ_ŋ ɹ_ˈiː_dʒ_ə_n]\
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Segment of light and heavy chains of mouse and human immunoglobulins where the genes for the variable region upstream join those of the constant region downstream (an important part of the ANTIBODY DIVERSITY mechanism). In the joining region of the light chain are the genes coding for amino acids 96 to 107.
By DataStellar Co., Ltd
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.