IRREVERSIBLE CHOLINESTERASE INHIBITORS
\ɪɹɪvˈɜːsəbə͡l kˈɒla͡ɪnstəɹˌe͡ɪz ɪnhˈɪbɪtəz], \ɪɹɪvˈɜːsəbəl kˈɒlaɪnstəɹˌeɪz ɪnhˈɪbɪtəz], \ɪ_ɹ_ɪ_v_ˈɜː_s_ə_b_əl k_ˈɒ_l_aɪ_n_s_t_ə_ɹ_ˌeɪ_z ɪ_n_h_ˈɪ_b_ɪ_t_ə_z]\
Definitions of IRREVERSIBLE CHOLINESTERASE INHIBITORS
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Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
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