INSULINOMAS
\ˌɪnsuːlɪnˈə͡ʊməz], \ˌɪnsuːlɪnˈəʊməz], \ˌɪ_n_s_uː_l_ɪ_n_ˈəʊ_m_ə_z]\
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A tumor of the beta cells of the islets of Langerhans. Although usually benign, such tumors are among the most important causes of hypoglycemia. Insulinomas usually occur in patients between the ages of 20 and 75 years, the average age being 44-46. Women are 60% of the patients in most series. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1324)
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Immunologic Desensitization
- Immunosuppression by the administration increasing doses antigen. Though exact mechanism is not clear, therapy results increase in serum levels of allergen-IMMUNOGLOBULIN G, suppression specific IgE, and an suppressor T-cell activity.