INSERTIONAL MUTAGENESIS
\ɪnsˈɜːʃənə͡l mjˌuːte͡ɪd͡ʒˈɛnɪsˌɪs], \ɪnsˈɜːʃənəl mjˌuːteɪdʒˈɛnɪsˌɪs], \ɪ_n_s_ˈɜː_ʃ_ə_n_əl m_j_ˌuː_t_eɪ_dʒ_ˈɛ_n_ɪ_s_ˌɪ_s]\
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Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA can be inserted into or adjacent to a cellular proto-oncogene. Insertion of the provirus can cause mutations by interrupting coding sequences or regulatory elements, or cause unregulated expression of the proto-oncogene resulting in tumor formation.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.