INITIATION CODON
\ɪnˌɪʃɪˈe͡ɪʃən kˈɒdɒn], \ɪnˌɪʃɪˈeɪʃən kˈɒdɒn], \ɪ_n_ˌɪ_ʃ_ɪ__ˈeɪ_ʃ_ə_n k_ˈɒ_d_ɒ_n]\
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A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.