INHERITED SPINOCEREBELLAR DEGENERATION

\ɪnhˈɛɹɪtɪd spˈɪnə͡ʊsɹˌɛbɛlə dɪd͡ʒˌɛnəɹˈe͡ɪʃən], \ɪnhˈɛɹɪtɪd spˈɪnə‍ʊsɹˌɛbɛlə dɪd‍ʒˌɛnəɹˈe‍ɪʃən], \ɪ_n_h_ˈɛ_ɹ_ɪ_t_ɪ_d s_p_ˈɪ_n_əʊ_s_ɹ_ˌɛ_b_ɛ_l_ə d_ɪ_dʒ_ˌɛ_n_ə_ɹ_ˈeɪ_ʃ_ə_n]\

Definitions of INHERITED SPINOCEREBELLAR DEGENERATION

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MEN IIa

  • type multiple endocrine neoplasia characterized by virtually 100% incidence medullary thyroid carcinoma, a 50% pheochromocytoma, and lesser adenomas associated hyperparathyroidism. condition always transmitted through autosomal dominant inheritance. Genetic testing can identify individuals with the trait in early infancy. Treatment is usually excision of enlarged parathyroid glands. (From Holland et al., Cancer Medicine, 3d ed, pp1172-75)
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