IMPORTIN ALPHA
\ɪmpˈɔːtɪn ˈalfə], \ɪmpˈɔːtɪn ˈalfə], \ɪ_m_p_ˈɔː_t_ɪ_n ˈa_l_f_ə]\
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Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNAL of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUCCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
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Word of the day
tinctura quininae ammoniata
- A preparation made by dissolving quinin sulphate in alcohol [Br. Ph.].