IMMUNE ASSOCIATED ANTIGENS, HUMAN
\ɪmjˈuːn ɐsˈə͡ʊsɪˌe͡ɪtɪd ˈantɪd͡ʒˌɛnz], \ɪmjˈuːn ɐsˈəʊsɪˌeɪtɪd ˈantɪdʒˌɛnz], \ɪ_m_j_ˈuː_n ɐ_s_ˈəʊ_s_ɪ__ˌeɪ_t_ɪ_d ˈa_n_t_ɪ_dʒ_ˌɛ_n_z]\
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Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.