HYPOTHALAMO NEUROHYPOPHYSIAL REGION NEOPLASMS
\hˌa͡ɪpə͡ʊθˈaləmˌə͡ʊ njˌuːɹə͡ʊˌɪpəfˈɪzɪəl ɹˈiːd͡ʒən nˈiːə͡ʊplˌazəmz], \hˌaɪpəʊθˈaləmˌəʊ njˌuːɹəʊˌɪpəfˈɪzɪəl ɹˈiːdʒən nˈiːəʊplˌazəmz], \h_ˌaɪ_p_əʊ_θ_ˈa_l_ə_m_ˌəʊ n_j_ˌuː_ɹ_əʊ_ˌɪ_p_ə_f_ˈɪ_z_ɪ__ə_l ɹ_ˈiː_dʒ_ə_n n_ˈiː__əʊ_p_l_ˌa_z_ə_m_z]\
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Benign and malignant tumors of the HYPOTHALAMUS. Pilocytic astrocytomas and hamartomas are relatively frequent histologic types. Neoplasms of the hypothalamus frequently originate from adjacent structures, including the OPTIC CHIASM, optic nerve (see OPTIC NERVE NEOPLASMS), and pituitary gland (see PITUITARY NEOPLASMS). Relatively frequent clinical manifestions include visual loss, developmental delay, macrocephaly, and precocious puberty. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2051)
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.