HTLV III GP120
\ˌe͡ɪt͡ʃtˌiːˌɛlvˈiː ɹˌə͡ʊmən θɹˈiː d͡ʒˌiːpˈiː wˈɒnhˈʌndɹədən twˈɛnti], \ˌeɪtʃtˌiːˌɛlvˈiː ɹˌəʊmən θɹˈiː dʒˌiːpˈiː wˈɒnhˈʌndɹədən twˈɛnti], \ˌeɪ_tʃ_t_ˌiː__ˌɛ_l_v_ˈiː ɹ_ˌəʊ_m_ə_n_ θ_ɹ_ˈiː dʒ_ˌiː_p_ˈiː w_ˈɒ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n t_w_ˈɛ_n_t_i]\
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External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kD and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.