HOLMES ADIE SYNDROME
\hˈə͡ʊmz ˈe͡ɪdi sˈɪndɹə͡ʊm], \hˈəʊmz ˈeɪdi sˈɪndɹəʊm], \h_ˈəʊ_m_z ˈeɪ_d_i s_ˈɪ_n_d_ɹ_əʊ_m]\
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A syndrome characterized by a TONIC PUPIL that occurs in combination with decreased lower extremity reflexes. The affected pupil will respond more briskly to accommodation than to light (light-near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupillary constriction. Pathologic features include degeneration of the ciliary ganglion and postganglionic parasympathetic fibers that innervate the pupillary constrictor muscle. (From Adams et al., Principles of Neurology, 6th ed, p279)
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