GRADE IV ASTROCYTOMAS
\ɡɹˈe͡ɪd ɹˌə͡ʊmən fˈɔːɹ ˌastɹəsɪtˈə͡ʊməz], \ɡɹˈeɪd ɹˌəʊmən fˈɔːɹ ˌastɹəsɪtˈəʊməz], \ɡ_ɹ_ˈeɪ_d ɹ_ˌəʊ_m_ə_n_ f_ˈɔː_ɹ ˌa_s_t_ɹ_ə_s_ɪ_t_ˈəʊ_m_ə_z]\
Definitions of GRADE IV ASTROCYTOMAS
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A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
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