GRADE III ASTROCYTOMAS
\ɡɹˈe͡ɪd ɹˌə͡ʊmən θɹˈiː ˌastɹəsɪtˈə͡ʊməz], \ɡɹˈeɪd ɹˌəʊmən θɹˈiː ˌastɹəsɪtˈəʊməz], \ɡ_ɹ_ˈeɪ_d ɹ_ˌəʊ_m_ə_n_ θ_ɹ_ˈiː_ ˌa_s_t_ɹ_ə_s_ɪ_t_ˈəʊ_m_ə_z]\
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Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.