GENERALIZED STATUS EPILEPTICUS
\d͡ʒˈɛnəɹə͡lˌa͡ɪzd stˈe͡ɪtəs ˌɛpɪlˈɛptɪkəs], \dʒˈɛnəɹəlˌaɪzd stˈeɪtəs ˌɛpɪlˈɛptɪkəs], \dʒ_ˈɛ_n_ə_ɹ_əl_ˌaɪ_z_d s_t_ˈeɪ_t_ə_s ˌɛ_p_ɪ_l_ˈɛ_p_t_ɪ_k_ə_s]\
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A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338 (14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.