GANGLIONEUROBLASTOMAS
\ɡˌaŋɡlɪˌə͡ʊnjuːɹˌɒblastˈə͡ʊməz], \ɡˌaŋɡlɪˌəʊnjuːɹˌɒblastˈəʊməz], \ɡ_ˌa_ŋ_ɡ_l_ɪ__ˌəʊ_n_j_uː_ɹ_ˌɒ_b_l_a_s_t_ˈəʊ_m_ə_z]\
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A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.