GAMMA 1 IMMUNOGLOBULIN
\ɡˈamə wˈɒn ɪmjˈuːnəɡlˌɒbjʊlˌɪn], \ɡˈamə wˈɒn ɪmjˈuːnəɡlˌɒbjʊlˌɪn], \ɡ_ˈa_m_ə w_ˈɒ_n ɪ_m_j_ˈuː_n_ə_ɡ_l_ˌɒ_b_j_ʊ_l_ˌɪ_n]\
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Heavy chains found in the Fab and Fc fragments of IMMUNOGLOBULIN G and having a molecular weight of approximately 51 kD. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment. The gamma chains of the four IMMUNOGLOBULIN G subgroups are not identical, but resemble each other more closely than the heavy chains of a different immunoglobulin.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.