FRANKLIN DISEASE
\fɹˈaŋklɪn dɪzˈiːz], \fɹˈaŋklɪn dɪzˈiːz], \f_ɹ_ˈa_ŋ_k_l_ɪ_n d_ɪ_z_ˈiː_z]\
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A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N- (amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
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Vertebral Artery Dissection
- Dissection wall artery, leading to formation an aneurysm that occlude vessel. Thrombus give rise emboli. Cervical fractures or related NECK INJURIES and CRANIOCEREBRAL TRAUMA are commonly associated conditions, although this process may occur spontaneously. Ischemia, infarction, hemorrhage in the vascular distribution of affected vertebral artery complicate condition.