FOLIC ACID REDUCTASE
\fˈɒlɪk ˈasɪd ɹɪdˈʌkte͡ɪs], \fˈɒlɪk ˈasɪd ɹɪdˈʌkteɪs], \f_ˈɒ_l_ɪ_k ˈa_s_ɪ_d ɹ_ɪ_d_ˈʌ_k_t_eɪ_s]\
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An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
By DataStellar Co., Ltd
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Quinones
- Hydrocarbon rings which contain two moieties position. They can be substituted in any position except at the ketone groups.